Gene therapy treats muscle-wasting disease in dogs Fri, 17 Feb 2017 17:47:00 GMT Dogs with an inherited muscle-wasting disorder that was treated with a single infusion of corrective gene therapy were indistinguishable from normal animals one year later. Puppies with this naturally occurring, fatal genetic mutation and babies with the ... Read more
8 Dog Breeds That Like Being The Only Dog At Home Wed, 15 Feb 2017 14:30:00 GMT but some breeds were actually bred to be aggressive towards other dogs, so genetics play a big role in their temperament. If you're looking for a very friendly breed, we suggest you stick to dogs known for being social with other dogs and animals. Read more
Applied Science: Wolves, dogs and SNPs Sun, 19 Feb 2017 00:18:00 GMT This week's question: In AP biology class at NPHS students have been studying DNA technology and genetics. Students are currently working on an activity that involves dog SNPs (single nucleotide polymorphisms). SNPs (pronounced "snips"), are the most ... Read more
Gene Therapy Could Save Thousands of Dogs from Muscle-wasting Disease Thu, 16 Feb 2017 11:42:00 GMT It causes fatal muscle wasting. Both dogs and boys with the disease typically succumb in early life due to breathing difficulties. For decades, researchers have struggled to find suitable treatments for genetic muscle diseases like this one. Four ... Read more
Gene therapy treats myotubular myopathy in dogs Wed, 15 Feb 2017 23:10:00 GMT It causes fatal muscle wasting. Both dogs and boys with the disease typically succumb in early life due to breathing difficulties. For decades, researchers have struggled to find suitable treatments for genetic muscle diseases like this one. Four ... Read more
Genetics and the Social Behavior of Dogs A classic study gathered into one volume. Based on twenty years of research at the Jackson Laboratory, this is the single most important and comprehensive reference work.
Canine Genetics section of the Working Dogs Book Store features genetic studies and reference resources.
Note: The two resources immediately below are particularly helpful for reviewing the basics before ramping up to more advanced discussions about canine genetics:
Berkeley professors Melissa DeMille and C. Denise Wall present the Bare Bones Introduction to Genetics that introduces the major terms and concepts customarily used when discussing canine genetics.
In the Canine Genetic Primer, a cadre of genetics professionals collaborate to create an excellent resource for basic canine genetics on the Acmepet web site.
Canine Inherited Disorders Database intends to reduce the incidence of inherited disorders in dogs by providing information to owners and breeders, and to facilitate the best management possible of these conditions by providing current information to veterinarians. Featuring general information about inherited disorders and the breeds affected, particularly well done is their section "How Are Defects Inherited?". The site is under development with anticipated completion by 2001.
In their six-part series, authors Susan Thorpe-Vargas, John Cargill and Caroline Coile discuss how a single breeder's actions may have consequences that are far-reaching. Selective breeding practices may have created a genetic nightmare for many of our breeds today. In the first installment of that series, The Genetic Cul-de-Sac, the genetics task force addresses the origin of the domestic dog with an emphasis on the fundamentals of DNA and gene mutations, and their relationship to vigorous genetic diversity.
Prof. Sue Ann Bowling's Animal Color Genetics page features an excellent library of articles about population genetics, canine coat color genetics, inheritance, inbreeding, and much more.
UNE's GENUP software contains a number of learning modules. Each of these is designed to help you master concepts in Quantitative Genetics and its application to Animal Breeding.
"Heritability" is a statistic used to evaluate dogs and selectively breed them for a quantitative trait. Cornell geneticist John Pollack explains how Heritability Measures the Variability of Genes that can control physical characteristics.
The Canine Diversity web site features Genetic Testing: A Guide for Breeders by Mary Whiteley, PhD. Dr. Whiteley believes that we will soon have a test for most of the genetic diseases of dogs. In her article, she discusses genes, DNA, the genetic testing that is available to breeders today, and what the test results mean. Also on this site -- information about subscribing to the CANGEN email list for discussions about canine genetics and related topics.
Dealing effectively with any genetic problem requires an understanding of the relationship between the genes (genotype) and the phenotype. In his article, The Nature of Genetic Disease, Dr. John B. Armstrong sheds light on the differences between true genetic diseases and conformational diseases.
Online Mendelian Inheritance in Animals (OMIA) presented by the Dept. of Animal Science at the University of Sydney, Australia includes information about species, genetic maps, traits, and disorders,, such as inherited bleeding disorders, dwarfism, heart defects, and more.
Michigan University presents Laboratory of Molecular Medicine and Canine Genetics, "using the powerful new tools of molecular genetics to understand, improve diagnosis and treatment of, and ultimately prevent the hereditary diseases that affect dogs and (B) to educate and train veterinary professionals and scientists in molecular genetics and medicine."
The Dogs in Canada web site features Siberian Husky breeder Jeffrey Bragg's commentary on the upsurge of genetic problems and his call for action in The Genetic Tide: Will It Leave Us High and Dry? We are seeing a steady increase in genetic defects. Bragg suggests that the answer lies in the well-proven science of population genetics.
Fred Hutchinson Cancer Research Center's Current Canine Linkage Map of the canine genome with mapped markers, pedigrees, and resources.
The Dog Map is "an international collaboration between 46 labs from 20 different countries towards a low resolution canine marker map under the auspices of the International Society for Animal Genetics (ISAG)."
Dr. John B. Armstrong's Canine Diversity Project acquaints breeders of domesticated dogs with the dangers of inbreeding and the overuse of pre-eminent males.
The Control of Genetic Disease is discussed in a summary of information presented at seminars by Dr. George A. Padgett, DVM, a veterinary pathologist specializing in canine genetics.
The Open Disease Registry established by the Institute for Genetic Disease Control in Animals is the first open registry in the United States. Learn how the GDC helps the dog-owning public and responsible breeders identify and prevent genotypic and phenotypic disease.
Guide to Hereditary and Congenital Diseases in Dogs (Includes Genetic Predisposition to Diseases). Published by The Association of Veterinarians for Animal Rights. Includes a list of 148 purebred dog breeds with their genetic predisposition to diseases; plus an alphabetical listing and brief description of the genetically transmitted diseases.
Canadian Jeffrey Bragg details his arguments for achieving genetic soundness in his stimulating brief, Purebred Dog Breeds into the Twenty-First Century: Achieving Genetic Health for Our Dogs. Promoting a balanced, heterozygous breeding system, he focuses on the tremendous amount of work that is required of responsible breeders to preserve and advance canine working abilities. His model for genetic diversity demands a rational balance between working characteristics and the ideals of conformation.